姓名：洪明

性別：男

職稱：副研究員

學術兼職：（高校服務國家重大戰略出版工程“抗腫瘤中藥現代研究與臨床應用”編委）

地址：中山市人民醫院先進診斷與先進治療臨床研究中心

E-mail：hongming530[at]126[dot]com

個人簡歷：

2004.09~2008.07 江西中醫藥大學生物工程系學習，獲生物工程學士學位

2008.07~2011.07軍事醫學科學院基礎醫學研究所學習獲遺傳學碩士學位

2011.07~2011.12 華大基因分子診斷高級專員

2013.01~2013.04 香港大學解剖系研究助理2013.05~2017.09香港大學醫學部學習獲中藥藥理學博士學位

2017.12~2020.12廣州中醫藥大學科技創新中心副研究員碩士生導師

2018.06~2018.07  美國堪薩斯大學藥理與毒理系訪問學者

2021.01~2022.03  廣州大學中山市人民醫院生命醫學聯合研究院獨立PI   副研究員

2022.04至今 中山市人民醫院先進診斷與先進治療臨床研究中心 副研究員

主要研究方向（課題）：

　　主要從事中藥抗腫瘤活性及其分子機制的研究工作。綜合利用網絡藥理學，分子對接技術以及體內，體外試驗預測中藥的抗腫瘤活性成分及其分子機制。主要研究方向天然藥物抗腫瘤分子機制的研究。

代表性論文、論著和成果：

[1] Ming Hong , Tin Lan, Qiuxia Li, BinfeiLi Yong Yuan, Feng Xu , Weijia Wang. A comprehensive perspective on theinteraction between gut microbiota and COVID-19 vaccines. Gut Microbes. 2023Jan-Dec;15(1):2233146. (IF：12.2)

[2] Li SY, Wang WJ, Li QY, Yang PH, Li XL,Yan Y, Yuan Y, Feng YB, Hong M*. Using omics approaches to dissect thetherapeutic effects of Chinese herbal medicines on gastrointestinal cancers.Front Pharmacol. 2022 Sep 23;13:884822. doi: 10.3389/fphar.2022.884822.eCollection 2022.

[3] Ming Hong*, Mohammed M.Almutairi，Siying Li, Jinke Li* Wogonin inhibits cell cycle progression byactivating the glycogen synthase kinase-3 beta in hepatocellular carcinoma.Phytomedicine. 2020 Jan 18;68:153174.

[4] Bingyu SUN, Yongqiang LIU, Danhua HE,Jinke LI, Jiawei WANG, Wulin WEN*, Ming HONG*, 2021. Traditional Chinesemedicines and their active ingredients sensitizecancer cells to TRAIL-inducedapoptosis. Journal of Zhejiang University-Science B (Biomedicine &Biotechnology), 22(3):190-203(IF:3.1 JCR 2區) (IF：6.543 JCR 1區)

[5] Yi Luo, Yu Feng, Lei Song, Gan-Qing He,Sha Li, Sha-Sha Bai, Yu-Jie Huang, Si-Ying Li, Mohammed M. Almutairi, Hong-LianShi, Qi Wang, Ming Hong*. A network pharmacology-based study on theanti-hepatoma effect of Radix Salviae Miltiorrhizae. Chinese Medicine. 2019; 14

[6] Lei Song, Yi Luo, Yue-xin Wang,Mohammed M.Almutairi, Feng-hua Pan, Rong-wei Li, Qiang yong Liu, Qi Wang*, MingHong*. Exploring the Active Mechanism of Berberine Against HepatocellularCarcinoma by Systematic Pharmacology and Experimental Validation.Molecular  Medicine Reports. 2019 Volume20 Issue 5 https://doi.org/10.3892/mmr.2019.10698  

[7] Hong M#, Shi H#, Wang N, Tan HY, WangQ*, Feng Y* Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancerand Ischemic Stroke Treatments: Role of HIF-1 Network. Front Pharmacol. 2019Jun 26;10:696. doi: 10.3389/fphar.2019.00696. eCollection 2019.

[8] Ming Hong*#, Zhe Cai#, Lei Song,Yongqiang Liu, Qi Wang* and Xiangfei Feng*. Gynostemma pentaphyllum attenuatesthe progression of Non-alcoholic fatty liver disease in Mice: a biomedicalinvestigation integrated with in silico assay. Evidence-Based Complementary andAlternative Medicine. Volume 2018, Article ID 8384631, 13 pages

[9] Ming Hong*#, Honghui Cheng#, Lei Song,Wencai Wang, Qi Wang, Donggang Xu and Weiwei Xing*. Wogonin Suppresses theActivity of Matrix Metalloproteinase-9 and Inhibits Migration and Invasion inHuman Hepatocellular Carcinoma. Molecules. 2018, 23(2), 384;doi:10.3390/molecules23020384.

[10] Ming Hong#, Yongsheng Zhang#, Sha Li,Hor Yue Tan, Ning Wang, Shuzhen Mu, Xiaojiang Hao，Yibin Feng*. A Network Pharmacology-Based Study on theHepatoprotective Effect of Fructus Schisandrae. Molecules. 2017, 22(10), 1617;doi:10.3390/molecules22101617.

[11] Hong M, Li S, Tan HY, Cheung F, WangN, Huang J, Feng Y*. A Network-Based Pharmacology Study of the Herb-InducedLiver Injury Potential of Traditional Hepatoprotective Chinese HerbalMedicines. Molecules. 2017, 22(4), 632; doi:10.3390/molecules22040632.

[12] Hong M, Li S, Wang N, Tan HY, CheungF, Feng Y*. A Biomedical Investigation on the Hepatoprotective Effect of RadixSalviae Miltiorrhizae and Network pharmacology-based Prediction of the Activecompunds and Molecular Targets. Int. J. Mol. Sci. 2017, 18(3), 620;doi:10.3390/ijms18030620.

[13] Hong M, Tan HY, Li S, Cheung F, Wang NNagamatsu T, Feng Y*. Cancer Stem Cells: The Potential Targets of ChineseMedicines and Their Active Compounds. Int J Mol Sci. 2016. 17(6).  

[14] Hong M, Wang N, Tan HY, Tsao SW, FengY*. MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy.Cancers (Basel). 2015. 7(3): p. 1643-57.

[15] Ming Hong, Sha Li, Hor Yue Tan, NingWang, Sai-Wah Tsao and Yibin Feng. Current Status of Herbal Medicines inChronic Liver Disease Therapy: The Biological Effects, Molecular Targets andFuture Prospects. Int. J. Mol. Sci. 2015, 16(12), 28705-28745.

[16] Cai Z#, Hong M#, Xu L, Yang K, Li C,Sun T, Feng Y, Zeng H, Lu WW, Chiu KY. Prevent action of magnoflorine withhyaluronic acid gel from cartilage degeneration in anterior cruciate ligamenttransection induced osteoarthritis. Biomed Pharmacother. 2020 Jun;126:109733.

[17] Luo Y, Song L, Wang X, Huang Y, Liu Y,Wang Q, Hong M* and Yuan Z*. Uncovering the Mechanisms of Cryptotanshinone as aTherapeutic Agent Against Hepatocellular Carcinoma. Front. Pharmacol. 11:1264.

[18] Hong M, Zha L, Fu W, Zou M, Li W, XuD. A modified visual loop-mediated isothermal amplification method fordiagnosis and differentiation of main pathogens from Mycobacterium tuberculosiscomplex. World J Microbiol Biotechnol. 2012 Feb;28(2):523-31.

1. 國家自然科學基金（24萬），項目編號：820041612021.1-2023.12 負責人：洪明

2.廣東省基礎與應用基礎研究基金項目（10萬），項目編號: 2019A15151101672020.1-2021.12 負責人：洪明

3. 2022年度中山市第三批社會公益與基礎研究項目（重點項目）（15萬）項目編號：20428084378410 2023.1-2024.12負責人：洪明

獲得榮譽：

　　香港大學醫學部2017屆優秀博士論文